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PRI2 synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The replication of DNA is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.7.-; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transferase
Chromosomal Location of Human Ortholog: 6p11.2
Cellular Component: alpha DNA polymerase:primase complex; nucleoplasm
Molecular Function: DNA primase activity; DNA-directed DNA polymerase activity; single-stranded DNA binding
Biological Process: DNA replication initiation; G1/S transition of mitotic cell cycle; telomere maintenance via recombination
Reference #:  P49643 (UniProtKB)
Alt. Names/Synonyms: dJ422B11.1.1; DNA primase 58 kDa subunit; DNA primase large subunit; DNA primase polypeptide 2; DNA primase subunit p58; MGC75142; p58; polypeptide 2A, p58; PRI2; PRIM2; PRIM2A; primase polypeptide 2A, 58kDa; primase, DNA, polypeptide 2 (58kDa); primase, polypeptide 2A (58kD)
Gene Symbols: PRIM2
Molecular weight: 58,806 Da
Basal Isoelectric point: 7.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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