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SMYD3 Histone methyltransferase. Specifically methylates 'Lys- 4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences. Belongs to the histone-lysine methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Methyltransferase; Methyltransferase, protein lysine
Chromosomal Location of Human Ortholog: 1q44
Cellular Component: nucleoplasm; nucleus
Molecular Function: histone-lysine N-methyltransferase activity; protein binding
Reference #:  Q9H7B4 (UniProtKB)
Alt. Names/Synonyms: bA74P14.1; bA74P14.1 (novel protein); FLJ21080; KMT3E; MGC104324; SET and MYND domain containing 3; SET and MYND domain-containing protein 3; SMYD3; Zinc finger MYND domain-containing protein 1; zinc finger protein, subfamily 3A (MYND domain containing), 1; zinc finger, MYND domain containing 1; ZMYND1; ZNFN3A1
Gene Symbols: SMYD3
Molecular weight: 49,097 Da
Basal Isoelectric point: 7.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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