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RACK1 a G-beta like protein containing 7 WD domains. A presumptive scaffold protein, linking protein kinase C to its substrates. Binds inositol 1,4,5-trisphosphate receptors and regulates Ca2+ release by enhancing inositol 1,4,5-trisphosphate receptor binding affinity for inositol 1,4,5-trisphosphate. An insulin-like growth factor 1 receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: cell soma; cytoplasm; cytosol; dendrite; extracellular exosome; IRE1-RACK1-PP2A complex; midbody; mitochondrion; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm; phagocytic cup; small ribosomal subunit
Molecular Function: cadherin binding; caspase activator activity; cyclin binding; enzyme binding; ion channel inhibitor activity; protein binding; protein complex scaffold activity; protein homodimerization activity; protein kinase C binding; protein phosphatase binding; protein tyrosine kinase inhibitor activity; receptor binding; receptor tyrosine kinase binding; ribosome binding; RNA binding; SH2 domain binding
Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptosis; cell cycle; cellular response to glucose stimulus; cellular response to growth factor stimulus; gastrulation; negative regulation of cell growth; negative regulation of endoplasmic reticulum unfolded protein response; negative regulation of gene expression; negative regulation of peptidyl-serine phosphorylation; negative regulation of phagocytosis; negative regulation of protein kinase B signaling cascade; negative regulation of translation; negative regulation of Wnt signaling pathway; pigmentation; positive regulation of apoptosis; positive regulation of cAMP catabolic process; positive regulation of cell migration; positive regulation of ceramide biosynthetic process; positive regulation of cyclic-nucleotide phosphodiesterase activity; positive regulation of gastrulation; positive regulation of Golgi to plasma membrane protein transport; positive regulation of GTPase activity; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of mitochondrial depolarization; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein homooligomerization; positive regulation of protein phosphorylation; protein ubiquitination; regulation of cell cycle; regulation of cell division; regulation of establishment of cell polarity; regulation of protein localization; regulation of tumor necrosis factor-mediated signaling pathway; rescue of stalled ribosome; rhythmic process; viral process
Reference #:  P63244 (UniProtKB)
Alt. Names/Synonyms: Cell proliferation-inducing gene 21 protein; GBLP; Gnb2-rs1; GNB2L1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; Guanine nucleotide-binding protein subunit beta-2-like 1; Guanine nucleotide-binding protein subunit beta-like protein 12.3; H12.3; HLC-7; Human lung cancer oncogene 7 protein; lung cancer oncogene 7; PIG21; proliferation-inducing gene 21; protein homologous to chicken B complex protein, guanine nucleotide binding; RACK1; Receptor for activated C kinase; Receptor for Activated C Kinase 1; Receptor of activated protein kinase C 1
Gene Symbols: RACK1
Molecular weight: 35,077 Da
Basal Isoelectric point: 7.6  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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