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VDAC1 a protein of the eukaryotic mitochondrial porin family. Forms a voltage-dependent anion channel through the mitochondrial outer membrane and also the plasma membrane. The channel allows diffusion of small hydrophilic molecules; it adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: membrane; mitochondrial outer membrane; mitochondrion; nucleus; plasma membrane; pore complex
Molecular Function: protein binding; protein kinase binding; voltage-gated anion channel activity
Biological Process: anion transport; apoptosis; epithelial cell differentiation; macroautophagy
Reference #:  P21796 (UniProtKB)
Alt. Names/Synonyms: hVDAC1; MGC111064; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; PORIN; Porin 31HL; Porin 31HM; PORIN-31-HL; VDAC; VDAC-1; VDAC1; voltage-dependent anion channel 1; Voltage-dependent anion-selective channel protein 1
Gene Symbols: VDAC1
Molecular weight: 30,773 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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