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DDX5 a putative ATP-dependent RNA helicase. A proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Belongs to the DEAD box helicase family. DDX5/DDX17 subfamily. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Note: This description may include information from UniProtKB.
Protein type: EC; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 17q23.3
Cellular Component: cytoplasm; extracellular matrix; membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex
Molecular Function: androgen receptor binding; ATP-dependent RNA helicase activity; estrogen receptor binding; mRNA 3'-UTR binding; protein binding; ribonucleoprotein binding; RNA binding; RNA helicase activity; SMAD binding; transcription coactivator activity
Biological Process: alternative nuclear mRNA splicing, via spliceosome; androgen receptor signaling pathway; BMP signaling pathway; epithelial to mesenchymal transition; estrogen receptor signaling pathway; mRNA transcription; myoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of estrogen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; regulation of alternative nuclear mRNA splicing, via spliceosome; regulation of osteoblast differentiation; regulation of transcription from RNA polymerase II promoter; RNA secondary structure unwinding
Reference #:  P17844 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent RNA helicase DDX5; DDX5; DEAD (Asp-Glu-Ala-Asp) box polypeptide 5; DEAD box protein 5; DEAD box-5; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD); DKFZp434E109; DKFZp686J01190; G17P1; HELR; HLR1; HUMP68; p68; Probable ATP-dependent RNA helicase DDX5; RNA helicase p68
Gene Symbols: DDX5
Molecular weight: 69,148 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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