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Protein Page:
profilin 1

profilin 1 a ubiquitous actin monomer-binding protein belonging to the profilin family. At high concentrations, profilin 1 prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Deletion of this gene is associated with Miller-Dieker syndrome. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component: cell cortex; cytoplasm; cytosol; focal adhesion; membrane; nucleus
Molecular Function: actin binding; actin monomer binding; adenyl-nucleotide exchange factor activity; cadherin binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; RNA binding
Biological Process: negative regulation of actin filament bundle formation; negative regulation of actin filament polymerization; negative regulation of stress fiber formation; positive regulation of actin filament bundle formation; positive regulation of actin filament polymerization; positive regulation of ATPase activity; protein stabilization; Wnt receptor signaling pathway, planar cell polarity pathway
Disease: Amyotrophic Lateral Sclerosis 18
Reference #:  P07737 (UniProtKB)
Alt. Names/Synonyms: PFN1; PROF1; profilin 1; Profilin I; Profilin-1
Gene Symbols: PFN1
Molecular weight: 15,054 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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profilin 1

Protein Structure Not Found.
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