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ACTA1 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TTID. Interacts (via its C-terminus) with USP25; the interaction occurs for all USP25 isoforms but is strongest for isoform USP25m in muscle differentiating cells. Belongs to the actin family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q42.13
Cellular Component: actin cytoskeleton; actin filament; cytosol; extracellular space; filopodium; lamellipodium; sarcomere; stress fiber; striated muscle thin filament
Molecular Function: ADP binding; ATP binding; myosin binding; protein binding; structural constituent of cytoskeleton
Biological Process: muscle contraction; muscle filament sliding; muscle thin filament assembly; skeletal muscle fiber development
Disease: Myopathy, Congenital, With Fiber-type Disproportion; Myopathy, Scapulohumeroperoneal; Nemaline Myopathy 3
Reference #:  P68133 (UniProtKB)
Alt. Names/Synonyms: ACTA; ACTA1; actin, alpha 1, skeletal muscle; Actin, alpha skeletal muscle; ACTS; alpha skeletal muscle actin; Alpha-actin-1; ASMA; CFTD; CFTD1; CFTDM; MPFD; NEM1; NEM2; NEM3
Gene Symbols: ACTA1
Molecular weight: 42,051 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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