Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

RAB6A Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Interacts with CCDC64; leads to its accumulation in the pericentrosomal region. Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with RAB6IP1 (via its RUN 1 domain). Isoform 1 interacts with RAB6KIFL. Isoform 2 does not interact with RAB6KIFL. Isoform 1 interacts with BICD1. Isoform 2 interacts with BICD1. Isoform 1 interacts with BICD2. Isoform 2 interacts with BICD2. Interacts with TMF1. Isoform 1 (GTP-bound) interacts with DYNLRB1; the interaction is direct. Isoform 2 (GDP-bound) interacts with DYNLRB1; the interaction is direct. Interacts with PIFO/C1orf88. Ubiquitous. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11q13.4
Cellular Component: cytoplasmic vesicle; cytosol; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; membrane; plasma membrane; secretory granule membrane; trans-Golgi network; trans-Golgi network membrane
Molecular Function: GTP binding; GTPase activity; myosin V binding; protein binding; protein domain specific binding
Biological Process: antigen processing and presentation; neutrophil degranulation; peptidyl-cysteine methylation; protein localization in Golgi apparatus; protein targeting to Golgi; retrograde vesicle-mediated transport, Golgi to ER
Reference #:  P20340 (UniProtKB)
Alt. Names/Synonyms: GTP-binding protein RAB6A'; GTP-binding protein RAB6B; Oncogene RAB6; Rab GTPase; Rab-6; RAB6; RAB6, member RAS oncogene family; RAB6A; Rab6A variant 3; RAB6A'; RAB6A, member RAS oncogene family; RAB6B; Ras-related protein Rab-6A
Gene Symbols: RAB6A
Molecular weight: 23,593 Da
Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene