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INCENP Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1. Homodimer or heterodimer. Interacts with H2AFZ. Interacts with CBX3. Interacts with tubulin beta chain. Interacts with AURKB and AURKC. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts with EVI5. Interacts with CDCA8 and BIRC5; interaction is direct. Interacts with CBX5; POGZ and INCENP compete for interaction with CBX5. Interacts with POGZ. Interacts with JTB. Belongs to the INCENP family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC
Chromosomal Location of Human Ortholog: 11q12.3
Cellular Component: centric heterochromatin; chromosome, pericentric region; cytosol; kinetochore; midbody; nuclear body; nucleoplasm; nucleus; protein complex; spindle
Molecular Function: protein binding
Biological Process: chromosome segregation; cytokinesis; protein sumoylation; sister chromatid cohesion
Reference #:  Q9NQS7 (UniProtKB)
Alt. Names/Synonyms: binds and activates aurora-B and -C in vivo and in vitro; chromosomal passenger protein; FLJ31633; INCE; INCENP; Inner centromere protein; inner centromere protein antigens 135/155kDa; inner centromere protein INCENP; MGC111393
Gene Symbols: INCENP
Molecular weight: 105,429 Da
Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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