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ICAM1 a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: cell surface; external side of plasma membrane; extracellular matrix; extracellular space; focal adhesion; immunological synapse; integral component of plasma membrane; membrane; membrane raft; plasma membrane
Molecular Function: integrin binding; protein binding; receptor activity; transmembrane receptor activity; viral receptor activity
Biological Process: acute inflammatory response to antigenic stimulus; adhesion of symbiont to host; cell adhesion; cell adhesion mediated by integrin; cell aging; cellular response to nutrient levels; entry of virus into host cell; extracellular matrix organization; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; leukocyte adhesion; leukocyte migration; membrane to membrane docking; negative regulation of calcium ion transport; ovarian follicle development; positive regulation of actin filament polymerization; positive regulation of cellular extravasation; positive regulation of GTPase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of vasoconstriction; receptor-mediated virion attachment to host cell; regulation of cell shape; regulation of immune response; regulation of leukocyte mediated cytotoxicity; response to amino acid; response to amphetamine; response to copper ion; response to drug; response to ethanol; response to insulin stimulus; response to ionizing radiation; response to sulfur dioxide; sensory perception of sound; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; T cell antigen processing and presentation
Disease: Malaria, Susceptibility To
Reference #:  P05362 (UniProtKB)
Alt. Names/Synonyms: BB2; CD54; cell surface glycoprotein P3.58; human rhinovirus receptor; ICAM-1; ICAM1; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; Major group rhinovirus receptor; P3.58
Gene Symbols: ICAM1
Molecular weight: 57,825 Da
Basal Isoelectric point: 8.31  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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