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Catalase Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. Homotetramer. Belongs to the catalase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; Apoptosis; EC; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 11p13
Cellular Component: extracellular region; focal adhesion; intracellular membrane-bound organelle; membrane; mitochondrion; peroxisomal matrix; peroxisomal membrane; peroxisome
Molecular Function: antioxidant activity; catalase activity; enzyme binding; heme binding; NADP binding; oxidoreductase activity, acting on peroxide as acceptor; protein homodimerization activity; receptor binding
Biological Process: hydrogen peroxide catabolic process; negative regulation of apoptosis; neutrophil degranulation; osteoblast differentiation; protein homotetramerization; protein tetramerization; response to hydrogen peroxide; response to reactive oxygen species; UV protection
Disease: Acatalasemia
Reference #:  P04040 (UniProtKB)
Alt. Names/Synonyms: CAT; CATA; Catalase; MGC138422; MGC138424
Gene Symbols: CAT
Molecular weight: 59,756 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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