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STAR Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. May interact with TSPO. Expressed in gonads, adrenal cortex and kidney. Note: This description may include information from UniProtKB.
Protein type: Carrier; Lipid-binding; Mitochondrial
Chromosomal Location of Human Ortholog: 8p11.23
Cellular Component: mitochondrial intermembrane space
Molecular Function: cholesterol binding; protein binding
Biological Process: C21-steroid hormone biosynthetic process; steroid biosynthetic process
Disease: Lipoid Congenital Adrenal Hyperplasia
Reference #:  P49675 (UniProtKB)
Alt. Names/Synonyms: cholesterol trafficker; mitochondrial steroid acute regulatory protein; STAR; StAR-related lipid transfer (START) domain containing 1; STARD1; START domain containing 1; START domain-containing protein 1; steroid acute regulatory protein; steroidogenic acute regulator; steroidogenic acute regulatory protein; Steroidogenic acute regulatory protein, mitochondrial
Gene Symbols: STAR
Molecular weight: 31,914 Da
Basal Isoelectric point: 9.17  Predict pI for various phosphorylation states
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