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RAIG1 a G protein coupled receptor that is induced by all-trans retinoic acid (ATRA). Retinoic acids (RA) are a group of pleiotropic signaling molecules that regulate a broad range of physiologic and developmental processes. RAIG1 is expressed in lung tissue and in several lung cancer cell lines. This retinoic acid-inducible GPCR provides evidence for an interaction between retinoid and G-protein signaling pathways. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 12p13.1
Cellular Component: integral to plasma membrane; intracellular membrane-bound organelle; nucleolus; plasma membrane; vesicle
Molecular Function: cadherin binding; protein binding
Biological Process: negative regulation of epidermal growth factor receptor activity; signal transduction
Reference #:  Q8NFJ5 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor, family C, group 5, member A; G-protein coupled receptor family C group 5 member A; GPCR5A; GPRC5A; Orphan G-protein-coupling receptor PEIG-1; RAI3; RAIG-1; RAIG1; retinoic acid induced 3; retinoic acid responsive; Retinoic acid-induced gene 1 protein; Retinoic acid-induced protein 3
Gene Symbols: GPRC5A
Molecular weight: 40,251 Da
Basal Isoelectric point: 8.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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