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NHERF a scaffold protein that connects plasma membrane proteins with members of the Ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized beta-2-adrenergic receptor Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component: actin cytoskeleton; apical plasma membrane; cytoplasm; membrane; microvillus; microvillus membrane; nucleus; perinuclear region of cytoplasm; vesicle
Molecular Function: beta-2 adrenergic receptor binding; beta-catenin binding; chloride channel regulator activity; PDZ domain binding; phosphatase binding; protein binding; protein self-association; receptor binding
Biological Process: bile acid secretion; establishment of epithelial cell polarity; establishment of Golgi localization; establishment of nucleus localization; gland morphogenesis; microvillus biogenesis; negative regulation of cell proliferation; negative regulation of mitotic cell cycle; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of protein kinase B signaling cascade; protein complex assembly; regulation of cell shape; regulation of cell size; regulation of protein kinase activity
Disease: Nephrolithiasis/osteoporosis, Hypophosphatemic, 2
Reference #:  O14745 (UniProtKB)
Alt. Names/Synonyms: EBP50; ezrin-radixin-moesin binding phosphoprotein-50; Ezrin-radixin-moesin-binding phosphoprotein 50; Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Na+/H+ exchange regulatory co-factor; NHERF; NHERF-1; NHERF1; NHRF1; NPHLOP2; Regulatory cofactor of Na(+)/H(+) exchanger; SLC9A3R1; Sodium-hydrogen exchanger regulatory factor 1; sodium/hydrogen exchanger regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1; Solute carrier family 9 isoform A3 regulatory factor 1
Gene Symbols: SLC9A3R1
Molecular weight: 38,868 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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