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GRP58 a protein disulfide isomerase found in the endoplasmic reticulum lumen. Catalyzes the rearrangement of both intrachain and interchain disulfide bonds in proteins to form the native structures. An essential component of the peptide-loading complex of the major histocompatibility complex class I pathway. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Chaperone; EC; Endoplasmic reticulum; Isomerase; Phospholipase; Protease
Chromosomal Location of Human Ortholog: 15q15.3
Cellular Component: cell surface; endoplasmic reticulum; endoplasmic reticulum lumen; extracellular space; focal adhesion; nucleus; phagocytic vesicle; recycling endosome membrane
Molecular Function: cysteine-type endopeptidase activity; disulfide oxidoreductase activity; peptide disulfide oxidoreductase activity; phospholipase C activity; protein binding; protein disulfide isomerase activity; RNA binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; protein folding; protein import into nucleus; protein retention in ER; signal transduction
Reference #:  P30101 (UniProtKB)
Alt. Names/Synonyms: 58 kDa glucose-regulated protein; 58 kDa microsomal protein; Disulfide isomerase ER-60; endoplasmic reticulum P58; Endoplasmic reticulum resident protein 57; Endoplasmic reticulum resident protein 60; ER protein 57; ER protein 60; ER60; ERP57; ERP60; ERp61; glucose regulated protein, 58kDa; GRP57; GRP58; HsT17083; p58; PDIA3; phospholipase C-alpha; PI-PLC; protein disulfide isomerase family A, member 3; protein disulfide isomerase-associated 3; Protein disulfide-isomerase A3
Gene Symbols: PDIA3
Molecular weight: 56,782 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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