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FAF1 a pro-apoptotic protein that binds to FAS antigen. Potentiates but cannot initiate FAS-induced apoptosis. Its pro-apoptotic activity requires a ubiquitin-like domain but not the FAS-binding domain. Phosphorylation by protein kinase CK2 influences transport into nucleus. Two transcript variants encoding different protein isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 1p32.3
Cellular Component: cytosol; nucleus; perinuclear region of cytoplasm
Molecular Function: heat shock protein binding; NF-kappaB binding; protein binding; protein kinase binding; ubiquitin binding; ubiquitin protein ligase binding
Biological Process: cell death; cytoplasmic sequestering of NF-kappaB; positive regulation of protein complex assembly; regulation of protein catabolic process
Reference #:  Q9UNN5 (UniProtKB)
Alt. Names/Synonyms: CGI-03; FAF1; Fas (TNFRSF6) associated factor 1; FAS-associated factor 1; FLJ37524; hFAF1; HFAF1s; TNFRSF6-associated factor 1; UBX domain protein 3A; UBX domain-containing protein 12; UBX domain-containing protein 3A; UBXD12; UBXN3A
Gene Symbols: FAF1
Molecular weight: 73,954 Da
Basal Isoelectric point: 4.81  Predict pI for various phosphorylation states
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