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CD28 a type I plasma membrane protein Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Binds to B7-1 and -2. Expressed in T cells and plasma cells, but not in less mature B cells. Six splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q33.2
Cellular Component: cell surface; cytosol; external side of plasma membrane; immunological synapse; integral component of plasma membrane; plasma membrane
Molecular Function: coreceptor activity; identical protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protease binding; protein binding; protein kinase binding; SH3/SH2 adaptor activity
Biological Process: cell surface receptor signaling pathway; cytokine biosynthetic process; humoral immune response; negative thymic T cell selection; phosphatidylinositol phosphorylation; positive regulation of alpha-beta T cell proliferation; positive regulation of inflammatory response to antigenic stimulus; positive regulation of interleukin-10 production; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-4 production; positive regulation of isotype switching to IgG isotypes; positive regulation of mitotic nuclear division; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of translation; positive regulation of viral genome replication; regulation of defense response to virus by virus; regulation of regulatory T cell differentiation; regulatory T cell differentiation; T cell costimulation; T cell receptor signaling pathway
Reference #:  P10747 (UniProtKB)
Alt. Names/Synonyms: CD28; CD28 antigen; CD28 molecule; MGC138290; T-cell-specific surface glycoprotein CD28; TP44
Gene Symbols: CD28
Molecular weight: 25,066 Da
Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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