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EIF6 eukaryotic translation initiation factor 6. Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Translation; Translation initiation
Chromosomal Location of Human Ortholog: 20q11.22
Cellular Component: cytoplasm; cytosol; nucleolus; nucleoplasm; nucleus
Molecular Function: protein binding; ribosomal large subunit binding; ribosome binding
Biological Process: maturation of 5.8S rRNA; maturation of LSU-rRNA; mature ribosome assembly; miRNA-mediated gene silencing; miRNA-mediated gene silencing, negative regulation of translation; positive regulation of translation; regulation of fatty acid biosynthetic process; regulation of glycolysis; regulation of megakaryocyte differentiation; response to insulin stimulus; ribosome export from nucleus
Reference #:  P56537 (UniProtKB)
Alt. Names/Synonyms: 2; b; b(2)gcn; B(2)GCN homolog; B4 integrin interactor; CAB; eIF-6; EIF3A; EIF6; eukaryotic translation initiation factor 3A; Eukaryotic translation initiation factor 6; gcn; IF6; integrin beta 4 binding protein; ITGB4BP; p27 beta-4 integrin-binding protein; p27(BBP); p27BBP
Gene Symbols: EIF6
Molecular weight: 26,599 Da
Basal Isoelectric point: 4.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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