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ITGB4 integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Five alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component: cell junction; cell leading edge; cell surface; extracellular exosome; hemidesmosome; integrin complex; nucleus; plasma membrane; receptor complex
Molecular Function: G-protein coupled receptor binding; insulin-like growth factor I binding; neuregulin binding; protein binding; receptor activity
Biological Process: autophagy; cell adhesion; cell motility; cell-matrix adhesion; extracellular matrix organization; gut development; hemidesmosome assembly; integrin-mediated signaling pathway; mesodermal cell differentiation; renal system development; response to wounding; skin development
Disease: Epidermolysis Bullosa Junctionalis With Pyloric Atresia; Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa, Junctional, Non-herlitz Type
Reference #:  P16144 (UniProtKB)
Alt. Names/Synonyms: CD104; CD104 antigen; GP150; Integrin beta-4; integrin beta-4 subunit; integrin, beta 4; ITB4; ITGB4
Gene Symbols: ITGB4
Molecular weight: 202,167 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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