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galectin-3 galactose-specific lectin which binds IgE. Expressed at a high level in the colonic epithelium. Also abundant in activated macrophages. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Extracellular matrix; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14q22.3
Cellular Component: cytoplasm; extracellular matrix; extracellular space; immunological synapse; membrane; mitochondrial inner membrane; nucleus; plasma membrane; secretory granule membrane
Molecular Function: chemoattractant activity; IgE binding; laminin binding; protein binding; RNA binding
Biological Process: eosinophil chemotaxis; epithelial cell differentiation; macrophage chemotaxis; monocyte chemotaxis; negative regulation of endocytosis; negative regulation of T cell receptor signaling pathway; neutrophil chemotaxis; neutrophil degranulation; positive chemotaxis; regulation of T cell proliferation
Reference #:  P17931 (UniProtKB)
Alt. Names/Synonyms: 35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; CBP35; Gal-3; GAL3; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; Galectin-3; GALIG; IgE-binding protein; L-31; L31; Laminin-binding protein; Lectin L-29; lectin, galactoside-binding, soluble, 3; LEG3; LGALS2; LGALS3; Mac-2 antigen; MAC2
Gene Symbols: LGALS3
Molecular weight: 26,152 Da
Basal Isoelectric point: 8.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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