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NME1 an enzyme with multiple activities including histidine protein kinase, nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase and 3'-5' exonuclease activities. Plays a major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Involved in cell proliferation, differentiation and development, G protein-coupled receptor endocytosis, cytotoxic T cell and NK cell-mediated cell death, and gene expression. Required for neural development including neural patterning and cell fate determination. During granzyme A (GZMA)-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Three alternatively spliced human proteins have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, nucleoside diphosphate; Kinase, other; NDK family; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other group; Protein kinase, histidine; Tumor suppressor
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component: cytoplasm; cytosol; membrane; nucleus
Molecular Function: ATP binding; deoxyribonuclease activity; GTP binding; identical protein binding; magnesium ion binding; nucleoside diphosphate kinase activity; protein binding; ribosomal small subunit binding; RNA binding
Biological Process: negative regulation of cell proliferation; nucleobase, nucleoside and nucleotide interconversion; positive regulation of DNA binding; positive regulation of epithelial cell proliferation; regulation of apoptosis
Disease: Neuroblastoma, Susceptibility To
Reference #:  P15531 (UniProtKB)
Alt. Names/Synonyms: AWD; GAAD; Granzyme A-activated DNase; Metastasis inhibition factor nm23; NB; NBS; NDK A; NDKA; NDP kinase A; NDPK-A; NDPKA; NM23; nm23-H1; NME1; NME1A; non-metastatic cells 1, protein (NM23A) expressed in; Nucleoside diphosphate kinase A; Tumor metastatic process-associated protein
Gene Symbols: NME1
Molecular weight: 17,149 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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