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NRF2 a transcription factor that regulates basal expression and antioxidant induction of a transcription factor for NAD(P)H:quinone oxidoreductase-1 (NQO1) and other detoxifying genes. Targeted for proteasomal degradation by INrf2. Oxidative stress causes its phosphorylation and release from INrf2. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2q31.2
Cellular Component: centrosome; cytoplasm; cytosol; Golgi apparatus; nucleoplasm; nucleus; plasma membrane
Molecular Function: DNA binding; protein binding; protein domain specific binding; transcription factor activity
Biological Process: positive regulation of transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; protein ubiquitination; transcription from RNA polymerase II promoter; unfolded protein response
Reference #:  Q16236 (UniProtKB)
Alt. Names/Synonyms: HEBP1; NF-E2-related factor 2; NF2L2; NFE2-related factor 2; NFE2L2; NRF2; nuclear factor (erythroid-derived 2)-like 2; Nuclear factor erythroid 2-related factor 2; Nuclear factor, erythroid derived 2, like 2
Gene Symbols: NFE2L2
Molecular weight: 67,826 Da
Basal Isoelectric point: 4.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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