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GLT1 an integral membrane protein belonging to the sodium:dicarboxylate (SDF) symporter family. Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by co-transporting sodium. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 11p13
Cellular Component: cell surface; integral to plasma membrane; membrane; plasma membrane
Molecular Function: amino acid transmembrane transporter activity; glutamate:sodium symporter activity; high-affinity glutamate transmembrane transporter activity; L-glutamate transmembrane transporter activity; protein binding
Biological Process: glutamate secretion; ion transport; synaptic transmission
Disease: Epileptic Encephalopathy, Early Infantile, 41
Reference #:  P43004 (UniProtKB)
Alt. Names/Synonyms: EAA2; EAAT2; Excitatory amino acid transporter 2; excitotoxic amino acid transporter 2; glial high affinity glutamate transporter; GLT-1; GLT1; Glutamate/aspartate transporter II; SLC1A2; Sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; Solute carrier family 1 member 2; solute carrier family 1, member 2
Gene Symbols: SLC1A2
Molecular weight: 62,104 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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