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IFIT1 IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. Belongs to the IFIT family. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 10q23.31
Cellular Component: cytoplasm; cytosol
Molecular Function: protein binding; RNA binding
Biological Process: intracellular transport of viral proteins in host cell; negative regulation of defense response to virus by host; negative regulation of helicase activity; negative regulation of protein binding; negative regulation of viral genome replication; positive regulation of viral genome replication; response to virus
Reference #:  P09914 (UniProtKB)
Alt. Names/Synonyms: C56; G10P1; GARG-16; IFI-56; IFI-56K; IFI56; IFIT-1; IFIT1; IFNAI1; Interferon, alpha-inducible protein (MW 56kD); Interferon-induced 56 kDa protein; interferon-induced protein 56; Interferon-induced protein with tetratricopeptide repeats 1; ISG56; RNM561
Gene Symbols: IFIT1
Molecular weight: 55,360 Da
Basal Isoelectric point: 6.75  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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