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K19 a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 19 differs from all other IF proteins in lacking the C-terminal tail domain. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: costamere; cytosol; plasma membrane
Molecular Function: protein binding; structural constituent of cytoskeleton; structural constituent of muscle
Biological Process: keratinization; response to estrogen stimulus; sarcomere organization
Reference #:  P08727 (UniProtKB)
Alt. Names/Synonyms: 40-kDa keratin intermediate filament; CK-19; CK19; cytokeratin 19; Cytokeratin-19; K19; K1C19; K1CS; keratin 19; Keratin, type I cytoskeletal 19; keratin, type I, 40-kd; Keratin-19; KRT19; MGC15366
Gene Symbols: KRT19
Molecular weight: 44,106 Da
Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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