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SMAD9 transcription factor phosphorylated and activated by bone morphogenetic protein receptor kinases. Phosphorylated Smads dimerize with collaborating Smad4 and are translocated into the nucleus, where they regulate transcription of target genes. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Two alternatively spliced products have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 13q13.3
Cellular Component: cytoplasm; cytosol; intracellular; nucleoplasm; nucleus
Molecular Function: protein binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Biological Process: BMP signaling pathway
Disease: Pulmonary Hypertension, Primary, 2
Reference #:  O15198 (UniProtKB)
Alt. Names/Synonyms: MAD homolog 9; MADH6; MADH9; Mothers against decapentaplegic homolog 9; Mothers against decapentaplegic, drosophila, homolog of, 9; Mothers against DPP homolog 9; SMAD 9; SMAD family member 9; SMAD, mothers against DPP homolog 9; SMAD8; SMAD8A; SMAD8B; SMAD9
Gene Symbols: SMAD9
Molecular weight: 52,493 Da
Basal Isoelectric point: 7.87  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  TGF-ß Signaling
Select Structure to View Below


Protein Structure Not Found.

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