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MICU1 Key regulator of mitochondrial calcium uptake required for calcium entry into mitochondrion. May act as a calcium sensor via its EF-hand domains, gating the activity of a calcium channel partner. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. Belongs to the MICU1 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 10q22.1
Cellular Component: intracellular; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion
Molecular Function: calcium ion binding; identical protein binding; protein binding; protein heterodimerization activity
Biological Process: defense response; elevation of mitochondrial calcium ion concentration; mitochondrial calcium ion homeostasis; mitochondrial calcium ion transport; protein homooligomerization
Disease: Myopathy With Extrapyramidal Signs
Reference #:  Q9BPX6 (UniProtKB)
Alt. Names/Synonyms: ara CALC; atopy related autoantigen; Atopy-related autoantigen CALC; CALC; calcium binding atopy-related autoantigen 1; Calcium-binding atopy-related autoantigen 1; CBAA1; CBARA1; DKFZp564C246; EFHA3; FLJ12684; MICU1
Gene Symbols: MICU1
Molecular weight: 54,351 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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