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EGR3 a transcription factor involved in muscle spindle development and immune regulation. Egr2 and Egr3 induce the suppressive activity of CD4+ T cells, cooperatively inhibiting humoral immune responses by promoting TGFB3 secretion. Belongs to the EGR C2H2-type zinc-finger protein family. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 8p21.3
Molecular Function: transcription factor activity
Biological Process: cell migration during sprouting angiogenesis; circadian rhythm; muscle development; negative regulation of apoptosis; positive regulation of endothelial cell proliferation
Reference #:  Q06889 (UniProtKB)
Alt. Names/Synonyms: early growth response 3; Early growth response protein 3; EGR-3; EGR3; MGC138484; PILOT; Zinc finger protein pilot
Gene Symbols: EGR3
Molecular weight: 42,613 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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