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5-HT(4) This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. 8 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: cytoplasm; membrane; plasma membrane
Molecular Function: serotonin receptor activity; trace-amine receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; gamma-aminobutyric acid signaling pathway
Reference #:  Q13639 (UniProtKB)
Alt. Names/Synonyms: 5-HT-4; 5-HT4; 5-HT4R; 5-hydroxytryptamine (serotonin) receptor 4; 5-hydroxytryptamine receptor 4; 5-hydroxytryptamine4 receptor; 5HT4R; 5HTR4; cardiac 5-HT4 receptor; htr4; serotonin 5-HT4 receptor; serotonin receptor 4; Serotonin receptor 5-HT4
Gene Symbols: HTR4
Molecular weight: 43,761 Da
Basal Isoelectric point: 8.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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