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VEGFB Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. Homodimer; disulfide-linked. Can also form heterodimer with VEGF. Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: extracellular region; extracellular space
Molecular Function: growth factor activity; protein binding; vascular endothelial growth factor receptor 1 binding; vascular endothelial growth factor receptor 2 binding
Biological Process: angiogenesis; induction of positive chemotaxis; platelet degranulation; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; response to hypoxia; vascular endothelial growth factor receptor signaling pathway
Reference #:  P49765 (UniProtKB)
Alt. Names/Synonyms: Vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VEGFB; VEGFL; VRF
Gene Symbols: VEGFB
Molecular weight: 21,602 Da
Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis
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