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NGF Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Homodimer. Belongs to the NGF-beta family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p13.2
Cellular Component: cytoplasmic vesicle; endosome; extracellular region; Golgi lumen
Molecular Function: growth factor activity; metalloendopeptidase inhibitor activity; nerve growth factor receptor binding; protein binding
Biological Process: activation of MAPKK activity; caspase activation; cell-cell signaling; induction of apoptosis via death domain receptors; microtubule-based movement; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of neuron apoptosis; nerve growth factor processing; nerve growth factor receptor signaling pathway; neurite morphogenesis; phosphoinositide-mediated signaling; positive regulation of apoptosis; positive regulation of axonogenesis; positive regulation of Ras protein signal transduction; regulation of caspase activity; regulation of neuron differentiation; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Neuropathy, Hereditary Sensory And Autonomic, Type V
Reference #:  P01138 (UniProtKB)
Alt. Names/Synonyms: Beta-nerve growth factor; Beta-NGF; HSAN5; MGC161426; MGC161428; nerve growth factor (beta polypeptide); nerve growth factor, beta polypeptide; nerve growth factor, beta subunit; NGF; NGFB
Gene Symbols: NGF
Molecular weight: 26,959 Da
Basal Isoelectric point: 9.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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