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KHDRBS1 a nuclear RNA-binding protein. May be involved in slicing and mRNA transport. Associates with src in mitosis. Binds to RNA via a heteronuclear ribonucleoprotein K homology domain. Exerts functionally separable effects on cell proliferation and survival, dependent on its ability to bind specifically to RNA. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 1p35.2
Cellular Component: cytosol; membrane; nucleoplasm; nucleus
Molecular Function: DNA binding; identical protein binding; poly(A) binding; poly(U) binding; protein binding; protein domain specific binding; RNA binding; SH3/SH2 adaptor activity
Biological Process: cell cycle arrest; cell proliferation; cell surface receptor linked signal transduction; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent; positive regulation of RNA export from nucleus; positive regulation of translational initiation; protein oligomerization; regulation of protein stability; regulation of RNA export from nucleus; signal transduction
Reference #:  Q07666 (UniProtKB)
Alt. Names/Synonyms: FLJ34027; GAP-associated tyrosine phosphoprotein p62; GAP-associated tyrosine phosphoprotein p62 (Sam68); KH domain containing, RNA binding, signal transduction associated 1; KH domain-containing, RNA-binding, signal transduction-associated protein 1; KHDR1; KHDRBS1; p21 Ras GTPase-activating protein-associated p62; p62; p68; SAM68; Src-associated in mitosis 68 kDa protein
Gene Symbols: KHDRBS1
Molecular weight: 48,227 Da
Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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