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MyoD a transcription factor of the basic helix-loop-helix family and the myogenic factors subfamily. Involved in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. It is involved in muscle cell differentiation, and is essential for repair of damaged tissue. It activates its own transcription which may stabilize commitment to myogenesis. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; RNA splicing; Transcription factor
Chromosomal Location of Human Ortholog: 11p15.1
Cellular Component: cytosol; nuclear body; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex
Molecular Function: chromatin binding; chromatin DNA binding; nuclear hormone receptor binding; protein binding; protein heterodimerization activity; RNA polymerase II transcription factor activity, enhancer binding
Biological Process: muscle cell fate commitment; muscle development; myotube cell development; positive regulation of muscle cell differentiation; positive regulation of myoblast differentiation; positive regulation of skeletal muscle fiber development; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of RNA splicing; regulation of transcription from RNA polymerase II promoter; skeletal muscle development
Reference #:  P15172 (UniProtKB)
Alt. Names/Synonyms: BHLHC1; Class C basic helix-loop-helix protein 1; Myf-3; MYF3; Myoblast determination protein 1; MYOD; MYOD1; myogenic differentiation 1; Myogenic factor 3; PUM
Gene Symbols: MYOD1
Molecular weight: 34,501 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
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