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SPARC Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. Belongs to the SPARC family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5q33.1
Cellular Component: cell surface; cytoplasm; extracellular region; extracellular space; mitochondrion; nuclear matrix; plasma membrane; platelet alpha granule membrane
Molecular Function: calcium ion binding; collagen binding; extracellular matrix binding; protein binding
Biological Process: extracellular matrix organization and biogenesis; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; platelet degranulation; receptor-mediated endocytosis; regulation of cell morphogenesis
Disease: Osteogenesis Imperfecta, Type Xvii
Reference #:  P09486 (UniProtKB)
Alt. Names/Synonyms: Basement-membrane protein 40; BM-40; cysteine-rich protein; ON; Osteonectin; Secreted protein acidic and rich in cysteine; secreted protein, acidic, cysteine-rich (osteonectin); SPARC; SPRC
Gene Symbols: SPARC
Molecular weight: 34,632 Da
Basal Isoelectric point: 4.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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