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AQP2 Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Expressed in renal collecting tubules. Belongs to the MIP/aquaporin (TC 1.A.8) family. Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 12q13.12
Cellular Component: apical plasma membrane; integral to plasma membrane; membrane; plasma membrane
Molecular Function: glycerol transmembrane transporter activity; protein binding; water channel activity; water transporter activity
Biological Process: excretion; glycerol transport; renal water homeostasis; water transport
Disease: Diabetes Insipidus, Nephrogenic, Autosomal
Reference #:  P41181 (UniProtKB)
Alt. Names/Synonyms: ADH water channel; AQP-2; AQP-CD; AQP2; aquaporin 2 (collecting duct); Aquaporin-2; Aquaporin-CD; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; water-channel aquaporin 2; WCH-CD
Gene Symbols: AQP2
Molecular weight: 28,837 Da
Basal Isoelectric point: 6.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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