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AMSH an adaptor protein involved in cytokine signal transduction the JAK-STAT cascade. Binds to the SH3 domain of the signal-transducing adaptor molecule STAM (signal transducing adaptor molecule). May play a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Note: This description may include information from UniProtKB.
Protein type: EC; EC 3.4.19.-; Protease; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 2p13.1
Cellular Component: cleavage furrow; cytosol; nucleoplasm; nucleus; plasma membrane
Molecular Function: protein binding; protein domain specific binding; ubiquitin-specific protease activity
Biological Process: cytokinesis after mitosis; JAK-STAT cascade; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of Ras protein signal transduction; positive regulation of cell proliferation; protein deubiquitination
Disease: Microcephaly-capillary Malformation Syndrome
Reference #:  O95630 (UniProtKB)
Alt. Names/Synonyms: AMSH; Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase; MGC126516; MGC126518; STABP; STAM binding protein; STAM-binding protein; STAMBP
Gene Symbols: STAMBP
Molecular weight: 48,077 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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