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AMPKG1 a non-catalytic subunit of AMPK, a highly conserved kinase of the CAMKL family. The holoenzyme consists of a catalytic subunit (alpha) and two regulatory subunits (beta, gamma). Each subunit exists as multiple genetic isoforms giving rise to 12 different possible combinations of holoenzyme. Plays a key role in regulation of energy homeostasis. Activated by an elevated AMP-ATP ratio due to environmental stress, such as heat shock, hypoxia and ischemia. AMPK phosphorylates and regulates many metabolic enzymes. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 12q13.12
Cellular Component: AMP-activated protein kinase complex; cytosol; membrane; nucleoplasm
Molecular Function: ADP binding; AMP binding; AMP-activated protein kinase activity; ATP binding; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase regulator activity; protein binding; protein kinase activity; protein kinase binding
Biological Process: cell cycle arrest; macroautophagy; positive regulation of protein kinase activity; protein amino acid phosphorylation; regulation of glycolysis; regulation of macroautophagy; signal transduction; spermatogenesis
Reference #:  P54619 (UniProtKB)
Alt. Names/Synonyms: 5'-AMP-activated protein kinase subunit gamma-1; 5'-AMP-activated protein kinase, gamma-1 subunit; AAKG1; AMPK gamma-1 chain; AMPK gamma1; AMPK subunit gamma-1; AMPKg; MGC8666; PRKAG1; protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Gene Symbols: PRKAG1
Molecular weight: 37,579 Da
Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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