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ATG18 May play a role in autophagy. May regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. Probably interacts with androgen (AR) and the estrogen receptor (ER). Binds PtdIns3P and to a lesser extent, PtdIns3,5P2 and PtdIns5P in vitro. Interaction with PtdIns3P is required for recruitment to membranes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy
Chromosomal Location of Human Ortholog: 17q24.2
Cellular Component: cytoplasm; cytosol; endosome membrane; extrinsic to membrane; Golgi membrane; pre-autophagosomal structure membrane; trans-Golgi network
Molecular Function: androgen receptor binding; estrogen receptor binding; phosphatidylinositol 3-phosphate binding; receptor binding
Biological Process: autophagy; macroautophagy; mitochondrion degradation; protein amino acid lipidation; vesicle targeting, trans-Golgi to endosome
Reference #:  Q5MNZ9 (UniProtKB)
Alt. Names/Synonyms: ATG18; Atg18 protein homolog; FLJ10055; WD repeat domain phosphoinositide-interacting protein 1; WD repeat domain, phosphoinositide interacting 1; WD40 repeat protein interacting with phosphoinositides of 49 kDa; WD40 repeat protein Interacting with phosphoInositides of 49kDa; WIPI 49 kDa; WIPI-1; WIPI-1 alpha; WIPI1; WIPI49
Gene Symbols: WIPI1
Molecular weight: 48,673 Da
Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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