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TRAIL Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Homotrimer. Widespread; most predominant in spleen, lung and prostate. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q26.31
Cellular Component: extracellular region; integral component of plasma membrane
Molecular Function: cytokine activity; identical protein binding; protein binding; receptor binding; tumor necrosis factor receptor binding; zinc ion binding
Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptosis; cell surface receptor signaling pathway; cell-cell signaling; immune response; male gonad development; positive regulation of apoptosis; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; response to insulin stimulus; signal transduction
Reference #:  P50591 (UniProtKB)
Alt. Names/Synonyms: Apo-2 ligand; Apo-2L; APO2L; CD253; Protein TRAIL; TL2; TNF-related apoptosis inducing ligand TRAIL; TNF-related apoptosis-inducing ligand; TNF10; TNFSF10; TRAIL; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta; Tumor necrosis factor ligand superfamily member 10
Gene Symbols: TNFSF10
Molecular weight: 32,509 Da
Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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