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Protein Page:
14-3-3 epsilon

14-3-3 epsilon a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: cytoplasm; cytoplasmic vesicle membrane; cytosol; focal adhesion; membrane; nucleus; plasma membrane
Molecular Function: cadherin binding; calcium channel regulator activity; enzyme binding; histone deacetylase binding; phosphoprotein binding; phosphoserine binding; potassium channel regulator activity; protein binding; protein heterodimerization activity; Rab guanyl-nucleotide exchange factor activity; RNA binding; ubiquitin protein ligase binding
Biological Process: cytosolic calcium ion homeostasis; G2/M transition of mitotic cell cycle; MAPKKK cascade; negative regulation of caspase activity; positive regulation of protein export from nucleus; substantia nigra development
Disease: Miller-dieker Lissencephaly Syndrome
Reference #:  P62258 (UniProtKB)
Alt. Names/Synonyms: 14-3-3 epsilon; 14-3-3 protein epsilon; 14-3-3E; 1433E; FLJ45465; FLJ53559; KCIP-1; MDCR; MDS; mitochondrial import stimulation factor L subunit; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide; YWHAE
Gene Symbols: YWHAE
Molecular weight: 29,174 Da
Basal Isoelectric point: 4.63  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Hippo Signaling  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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14-3-3 epsilon

Protein Structure Not Found.
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