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TIMP1 Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Belongs to the protease inhibitor I35 (TIMP) family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: Xp11.3
Cellular Component: basement membrane; endoplasmic reticulum lumen; extracellular region; extracellular space; proteinaceous extracellular matrix
Molecular Function: cytokine activity; growth factor activity; metalloendopeptidase inhibitor activity; protease binding; protein binding; zinc ion binding
Biological Process: aging; cartilage development; cell activation; cellular protein metabolic process; extracellular matrix disassembly; negative regulation of apoptosis; negative regulation of catalytic activity; negative regulation of membrane protein ectodomain proteolysis; platelet degranulation; positive regulation of cell proliferation; post-translational protein modification; response to cytokine; response to hormone; response to peptide hormone; wound healing
Reference #:  P01033 (UniProtKB)
Alt. Names/Synonyms: CLGI; Collagenase inhibitor; EPA; EPO; erythroid potentiating activity; Erythroid-potentiating activity; Fibroblast collagenase inhibitor; FLJ90373; HCI; Metalloproteinase inhibitor 1; TIMP; TIMP metallopeptidase inhibitor 1; TIMP-1; TIMP1; tissue inhibitor of metalloproteinases; Tissue inhibitor of metalloproteinases 1
Gene Symbols: TIMP1
Molecular weight: 23,171 Da
Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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