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Plectin-1 a major cytoskeleton crosslinking protein that binds to actin, intermediate filaments and microtubules. A scaffold for proteins involved in cellular signaling. Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics. Regulates the organization of keratin intermediate filaments (IF) and MAPK signaling during cell migration. Downregulates PKC signaling by sequestering RACK1. Redistributes to the uropod associated with vimentin and fodrin during polarization of peripheral blood T lymphocytes. This vimentin-plectin-fodrin complex provides a continuous linkage from the nucleus (lamin B) to the cortical cytoskeleton. Defects in PLEC1 are the cause of epidermolysis bullosa simplex 1 (EBS1). Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: costamere; cytosol; extracellular matrix; focal adhesion; hemidesmosome; intermediate filament cytoskeleton; sarcolemma; sarcoplasm
Molecular Function: ankyrin binding; cadherin binding; protein binding; RNA binding; structural constituent of muscle
Biological Process: hemidesmosome assembly
Reference #:  Q15149 (UniProtKB)
Alt. Names/Synonyms: EBS1; EBSO; HD1; Hemidesmosomal protein 1; PCN; PLEC; PLEC1; PLEC1b; plectin; plectin 1, intermediate filament binding protein 500kDa; Plectin-1; PLTN
Gene Symbols: PLEC
Molecular weight: 531,791 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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