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NuMA-1 a coiled-coil nuclear protein that is required to establish and maintain mammalian spindle poles. Dissociates from condensing chromosomes during early prophase, before the complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident. Two human splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11q13.4
Cellular Component: cell cortex; centrosome; cytosol; extrinsic to plasma membrane; nuclear matrix; nucleoplasm; nucleus; protein complex; spindle; spindle microtubule; spindle pole; spindle pole centrosome
Molecular Function: microtubule binding; microtubule minus-end binding; microtubule plus-end binding; phosphoinositide binding; protein binding; protein C-terminus binding; structural molecule activity; tubulin binding
Biological Process: anastral spindle assembly; astral microtubule organization and biogenesis; establishment of mitotic spindle orientation; microtubule bundle formation; nuclear organization and biogenesis; positive regulation of BMP signaling pathway; positive regulation of chromosome segregation; positive regulation of hair follicle development; positive regulation of intracellular transport; positive regulation of keratinocyte differentiation; positive regulation of microtubule polymerization
Disease: Acute Promyelocytic Leukemia
Reference #:  Q14980 (UniProtKB)
Alt. Names/Synonyms: centrophilin stabilizes mitotic spindle in mitotic cells; Nuclear mitotic apparatus protein 1; NUMA; NuMA protein; NUMA1; SP-H antigen; structural nuclear protein
Gene Symbols: NUMA1
Molecular weight: 238,260 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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