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LAB linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: lipid raft; plasma membrane
Molecular Function: protein binding; SH2 domain binding
Biological Process: B cell activation; B cell receptor signaling pathway; calcium-mediated signaling
Reference #:  Q9GZY6 (UniProtKB)
Alt. Names/Synonyms: HSPC046; LAB; LAT2; linker for activation of B cells; Linker for activation of B-cells; linker for activation of T cells family, member 2; Linker for activation of T-cells family member 2; Membrane-associated adapter molecule; non-T cell activation linker; Non-T-cell activation linker; NTAL; WBS15; WBSCR15; WBSCR5; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosome region 15; Williams-Beuren syndrome chromosome region 5; WSCR5
Gene Symbols: LAT2
Molecular weight: 26,550 Da
Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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