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BIRC6 Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8. Expressed in brain cancer cells. Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 2p22.3
Cellular Component: endosome; Flemming body; Golgi apparatus; intracellular membrane-bound organelle; membrane; microtubule organizing center; midbody; spindle pole; trans-Golgi network
Molecular Function: cysteine-type endopeptidase inhibitor activity; protein binding; ubiquitin-protein transferase activity
Biological Process: apoptosis; cell cycle; cell division; negative regulation of apoptosis; negative regulation of endopeptidase activity; negative regulation of extrinsic apoptotic signaling pathway; positive regulation of cell proliferation; protein amino acid phosphorylation; protein ubiquitination; regulation of cell proliferation; regulation of cytokinesis
Reference #:  Q9NR09 (UniProtKB)
Alt. Names/Synonyms: APOLLON; baculoviral IAP repeat-containing 6; Baculoviral IAP repeat-containing protein 6; BIRC6; BRUCE; FLJ13726; FLJ13786; KIAA1289; Ubiquitin-conjugating BIR domain enzyme apollon; ubiquitin-conjugating BIR-domain enzyme apollon
Gene Symbols: BIRC6
Molecular weight: 530,255 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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