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SMAD4 transcription factor that mediates signal transduction by the transforming growth factor superfamily. The common smad (co-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. Promotes binding of the Smad2/Smad4/Fast-1 complex to DNA and provides an activation function required for Smad1 or Smad2 to stimulate transcription. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 18 E2|18 49.51 cM
Cellular Component: centrosome; cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleus; protein complex; transcription factor complex
Molecular Function: chromatin binding; collagen binding; DNA binding; filamin binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; SMAD binding; sulfate binding; transcription factor activity; transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
Biological Process: anterior/posterior pattern formation; axon guidance; BMP signaling pathway; cell proliferation; cellular iron ion homeostasis; developmental growth; embryonic digit morphogenesis; endoderm development; endothelial cell activation; female gonad development; formation of anatomical boundary; gastrulation; gastrulation with mouth forming second; in utero embryonic development; kidney development; male gonad development; mesoderm development; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of protein catabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neural crest cell differentiation; neuron fate commitment; osteoblast differentiation; ovarian follicle development; palate development; positive regulation of BMP signaling pathway; positive regulation of follicle-stimulating hormone secretion; positive regulation of histone H3-K4 methylation; positive regulation of luteinizing hormone secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of binding; regulation of cell proliferation; regulation of hair follicle development; regulation of transcription from RNA polymerase II promoter; regulation of transforming growth factor beta receptor signaling pathway; regulation of transforming growth factor-beta2 production; response to hypoxia; sebaceous gland development; single fertilization; SMAD protein complex assembly; somite rostral/caudal axis specification; spermatogenesis; tissue morphogenesis; transforming growth factor beta receptor signaling pathway; ureteric bud branching; uterus development; wound healing
Reference #:  P97471 (UniProtKB)
Alt. Names/Synonyms: AW743858; D18Wsu70e; Deletion target in pancreatic carcinoma 4 homolog; Dpc4; MAD homolog 4; MAD homolog 4 (Drosophila); Madh4; Mothers against decapentaplegic homolog 4; Mothers against DPP homolog 4; OTTMUSP00000023201; OTTMUSP00000023202; SMAD 4; SMAD family member 4; Smad4
Gene Symbols: Smad4
Molecular weight: 60,342 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  G1/S Checkpoint  |  SAPK/JNK Signaling Cascades  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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