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Barkor Required for both basal and inducible autophagy. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Forms a complex with BECN1, PIK3C3 and PIK3R4, but not with UVRAG, nor with KIAA0226/Rubicon. UVRAG and ATG14/Barkor form mutually exclusive complexes with BECN1 through direct competition. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy. Interacts with PIK3CB. Belongs to the Barkor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy
Chromosomal Location of Human Ortholog: 14q22.3
Cellular Component: autophagic vacuole; axoneme; cytosol; endoplasmic reticulum membrane; pre-autophagosomal structure membrane
Molecular Function: GTPase binding; protein binding
Biological Process: autophagic vacuole docking; autophagic vacuole formation; cellular response to glucose starvation; cellular response to starvation; endosome to lysosome transport; macroautophagy; macromitophagy; negative regulation of protein amino acid phosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of protein amino acid phosphorylation; regulation of protein amino acid phosphorylation
Reference #:  Q6ZNE5 (UniProtKB)
Alt. Names/Synonyms: ATG14; ATG14 autophagy related 14 homolog; Atg14L; Barkor; Beclin 1-associated autophagy-related key regulator; Beclin 1-Interacting protein; KIAA0831; MGC126291; MGC126292
Gene Symbols: ATG14
Molecular weight: 55,309 Da
Basal Isoelectric point: 6.59  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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