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EEF1A1 an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Translation; Translation elongation
Chromosomal Location of Human Ortholog: 6q13
Cellular Component: cortical actin cytoskeleton; cytoplasm; cytosol; eukaryotic translation elongation factor 1 complex; extracellular region; extracellular space; membrane; nucleolus; nucleus; plasma membrane
Molecular Function: GTP binding; GTPase activity; protein binding; protein kinase binding; RNA binding; translation elongation factor activity; tRNA binding
Biological Process: neutrophil degranulation; protein amino acid methylation; translational elongation
Reference #:  P68104 (UniProtKB)
Alt. Names/Synonyms: CCS-3; CCS3; cervical cancer suppressor 3; CTCL tumor antigen; EEF-1; EEF1A; eEF1A-1; EEF1A1; EF-1-alpha-1; EF-Tu; EF1A; EF1a-like protein; EF1A1; elongation factor 1 alpha subunit; Elongation factor 1-alpha 1; Elongation factor Tu; Eukaryotic elongation factor 1 A-1; eukaryotic translation elongation factor 1 alpha 1; eukaryotic translation elongation factor 1 alpha 1-like 14; FLJ25721; glucocorticoid receptor AF-1 specific elongation factor; GRAF-1EF; HNGC:16303; LENG7; leukocyte receptor cluster (LRC) member 7; Leukocyte receptor cluster member 7; MGC102687; MGC131894; MGC16224; prostate tumor-inducing protein 1; PTI1; translation elongation factor 1 alpha 1-like 14
Gene Symbols: EEF1A1
Molecular weight: 50,141 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
CST Pathways:  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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