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TCF3 Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. Down-regulates NQO1, leading to increased mitomycin c resistance. Belongs to the TCF/LEF family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 2p11.2
Cellular Component: cytosol; nucleoplasm; transcription factor complex
Molecular Function: beta-catenin binding; sequence-specific DNA binding
Biological Process: regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin
Reference #:  Q9HCS4 (UniProtKB)
Alt. Names/Synonyms: HMG box transcription factor 3; HMG-box transcription factor TCF-3; TCF-3; TCF3; TCF7L1; TF7L1; Transcription factor 7-like 1; transcription factor 7-like 1 (T-cell specific, HMG-box)
Gene Symbols: TCF7L1
Molecular weight: 62,631 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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