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CTNND1 an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. A downstream modulator of Wnt/beta-catenin signaling pathway whose stability may be regulated downstream of Dsh. Required for the invasiveness of E-cadherin-deficient cells. A signal coordinator between cadherins and Rho-family GTPases to regulate cytoskeletal changes required during dendritic spine and synapse development. The association of catenins with cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Thirty two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11q12.1
Cellular Component: cytoplasm; cytosol; intercellular junction; midbody; nucleus; plasma membrane
Molecular Function: cadherin binding; protein binding; receptor binding
Reference #:  O60716 (UniProtKB)
Alt. Names/Synonyms: Cadherin-associated Src substrate; CAS; catenin (cadherin-associated protein), delta 1; Catenin delta-1; CTND1; CTNND; CTNND1; KIAA0384; p120; p120 catenin; p120(cas); p120(ctn); P120CAS; P120CTN
Gene Symbols: CTNND1
Molecular weight: 108,170 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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